Anti-atherogenic Effect of Mulberry Leaf Tea in Atherogenic Index on Rats Dyslipidemia

Elvi Susanti(1*), Mohammad Sulchan(2), Endang Mahati(3)
(1) Universitas Diponegoro
(2) Department of Nutrition Science, Faculty of Medicine, Diponegoro University
(3) Department of Pharmacology, Faculty of Medicine, Diponegoro University
(*) Corresponding Author
DOI : 10.30604/jika.v7i3.1013

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by lipid fraction changes in the blood, such as an increase in total cholesterol, LDL, TG and a decrease in HDL, which is strongly associated with atherosclerosis. Mulberry leaves (Morus alba L.) contain quercetin and 1-deoxynojirimycin (DNJ), which help to lower cardiometabolic risk by reducing hyperlipidemia, oxidative stress and atherosclerosis. The objective of this study was to determine the effect of mulberry leaf tea (Morus alba L.) on the atherogenic index (AI) in Sprague Dawley rats with dyslipidemia. This study was true experimental research with a randomized pre and post-test control group design. A total of 30 male Sprague Dawley (SD) rats were randomly divided into five groups. Calculation of AI value: log (TG/HDL-C). Statistical analysis that was used was the paired t-test and one-way ANOVA test. The intervention of mulberry leaf tea with the dosage of 36 mg/100 g BW/day (P1) and 72 mg/100 g BW/day (P2) significantly reduced atherogenic index values. Simvastatin and P2 groups showed that there was no difference in atherogenic index values after the intervention. In conclusion, giving mulberry leaf tea reduced atherogenic index values in SD rats with dyslipidemia.

 

Abstrak: Dislipidemia merupakan kelainan metabolisme lipid yang ditandai dengan perubahan fraksi lipid dalam darah seperti peningkatan kolesterol total, LDL, TG dan penurunan HDL yang berhubungan kuat pada kejadian aterosklerosis. Daun mulberry (Morus alba L.) mengandung kuersetin dan 1-deoxynojirimycin (DNJ) yang berguna dalam menurunkan risiko kardiometabolik dengan menurunkan keadaan hiperlipidemia, stress oksidatif dan aterosklerosis. Tujuan dari penelitian ini untuk mengetahui pengaruh teh daun mulberry (Morus alba L.) terhadap indeks aterogenik plasma (IAP) pada tikus Sprague Dawley dislipidemia. Penelitian ini merupakan penelitian true experimental dengan randomized pre and post test control group design. Sebanyak 30 ekor tikus Sprague Dawley (SD) jantan dirandomisasi menjadi 5 kelompok. Rumus perhitungan nilai IAP : log (TG/HDL-C). Analisis statistik yang digunakan adalah uji paired t-test dan uji one-way ANOVA. Intervensi teh daun mulberry dosis 36 mg/100 g BB/hari (P1) dan 72 mg/100 g BB/hari (P2) secara signifikan menurunkan nilai indeks aterogenik plasma. Pada kelompok S dan kelompok P2 menunjukkan bahwa tidak terdapat perbedaan nilai indeks aterogenik plasma setelah intervensi. Sehingga disimpulkan bahwa pemberian teh daun mulberry terbukti menurunkan nilai indeks aterogenik plasma pada tikus SD dislipidemia.

Keywords


mulberry leaf tea; atherogenic index; atherosclerosis; dyslipidemia

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