Analysis Of Vitamin D Levels in The Population Infected with Covid-19
Abstract
The global pandemic of covid-19 is a problem faced by all nations in the world and until now there has not been found a drug that is truly capable of killing the covid-19 virus. Yet the death toll continues to fall around the world. Until the middle of August 2022, more than 150 thousand people have died from this disease in Indonesia (https://covid19.go.id). The vaccination program also has not reached 70%, therefore one alternative way that can be done by society is to avoid being exposed to the covid-19 by implementing health protocols and maintaining/ increasing body resistance. Recently, there have been studies reporting that there is a relationship between vitamin D levels in the blood and the immune system. This study aims to analyze the relationship between vitamin D levels in the blood and a history of being infected with COVID-19. This was an analytical survey study with a cross-sectional approach that examines the relationship between blood vitamin D/25(OH)D3 levels, vaccine completeness status, adherence to the 5M health protocol, age and gender with a history of being infected with COVID-19. The population in this study was all lecturers at Malahayati University Bandar Lampung, totaling 303 people, while the sample was 62 Malahayati University lecturers willing to be sampled. The sampling technique used was non-probability sampling: consecutive sampling. The collected data were analyzed using logistic regression. The results showed that there was a relationship between adherence to health protocols (pValue: 0.007) with OR 6.48 (95% CI: 1.67 – 15.4) and vitamin D levels in the blood (pValue: 0.045) with OR 3.13 (CI95%: 1.02 – 9.59). The more disobedient to the procedure and the lower the level of vitamin D in the blood can impact the greater the potential for infection with COVID-19. There is a need for continuous education to remind the importance of implementing health protocols and the need to increase the intake of vitamin D either from food or from pro-vitamin D biosynthesis in the skin with ultraviolet B/UVB.
Abstrak: The global pandemic of covid-19 is a problem faced by all nations in the world and until now there has not been found a drug that is truly capable of killing the covid-19 virus. Yet the death toll continues to fall around the world. Until the middle of August 2022, more than 150 thousand people have died from this disease in Indonesia (https://covid19.go.id). The vaccination program also has not reached 70%, therefore one alternative way that can be done by the society is to avoid being exposed to the covid-19 by implementing health protocols and maintaining/ increasing body resistance. Recently, there have been studies reporting that there is a relationship between vitamin D levels in the blood and the immune system. This study aims to analyze the relationship between vitamin D levels in the blood and a history of being infected with COVID 19. This was an analytical survey study with a cross-sectional approach that tries to examine the relationship between blood vitamin D/25(OH)D3 levels, vaccine completeness status, adherence to the 5M health protocol, age and gender with a history of being infected with COVID-19. The population in this study was all lecturers at Malahayati University Bandar Lampung, totaling 303 people, while the sample was 62 Malahayati University lecturers who were willing to be samples. The sampling technique used was non-probability sampling: consecutive sampling. The collected data were analyzed using logistic regression. The results showed that there was a relationship between adherence to health protocols (pValue: 0.007) with OR 6.48 (95% CI: 1.67 – 15.4) and vitamin D levels in the blood (pValue: 0.045) with OR 3.13 (CI95%: 1.02 – 9.59). The more disobedient to the procedure and the lower the level of vitamin D in the blood, can impact the greater the potential for infection with COVID-19. There is a need for continuous education to remind the importance of implementing health protocols and the need to increase the intake of vitamin D either from food or from pro-vitamin D biosynthesis in the skin with ultraviolet B/UVB.
Keywords
References
Abate, B. B., Kassie, A. M., Kassaw, M. W., Aragie, T. G., & Masresha, S. A. (2020). Sex difference in coronavirus disease (COVID-19): A systematic review and meta-analysis. BMJ Open, 10(10), 1–10. https://doi.org/10.1136/bmjopen-2020-040129
Ali, N. (2020). Role of vitamin D in preventing of COVID-19 infection, progression and severity. Journal of Infection and Public Health, 13(10), 1373–1380. https://doi.org/10.1016/j.jiph.2020.06.021
Asyary, A., & Veruswati, M. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company’s public news and information. Science of the Total Environment Jour, (January).
Bui, L., Zhu, Z., Hawkins, S., Cortez-Resendiz, A., & Bellon, A. (2021). Vitamin D regulation of the immune system and its implications for COVID-19: A mini-review. SAGE Open Medicine, 9, 205031212110140. https://doi.org/10.1177/20503121211014073
Chirumbolo, S., Bjørklund, G., Sboarina, A., & Vella, A. (2017). The Role of Vitamin D in the Immune System as a Pro-survival Molecule. Clinical Therapeutics, 39(5), 894–916. https://doi.org/10.1016/j.clinthera.2017.03.021
De Rui, M., Toffanello, E. D., Veronese, N., Zambon, S., Bolzetta, F., Sartori, L., … Sergi, G. (2014). Vitamin D deficiency and leisure time activities in the elderly: Are all pastimes the same? PLoS ONE, 9(4). https://doi.org/10.1371/journal.pone.0094805
Fakih, M., Oktaviana, S., Nurlaili, E., Febrianto, D., & Nargis, N. (2022). THE IMPLEMENTATION OF HEALTH PROTOCOLS ON E-COURT SYSTEMS DURING THE COVID-19 PANDEMIC ERA ( In Bandar Lampung City ), 6(1), 21–32. https://doi.org/10.25041/cepalo.v6no1.2584
Hall, J. E. (2015). Guyton and Hall review physiology (13th ed.). Philadelphia: Sauders-Elsevier.
Hermawan, D. (2021). Manfaat Vitamin D pada Era Pandemi Covid-19. Yogyakarta, Indonesia: Penerbit Buku Andi. Retrieved from https://books.google.co.id/books?id=kNA3EAAAQBAJ&printsec=frontcover&hl=id&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
Hermawan, D., & Hidayat, N. A. (2022). Pengaruh paparan sinar matahari pada penderita diabetes melitus tipe 2. Holistik Jurnal Kesehatan, 16(1), 35–41. https://doi.org/10.33024/hjk.v16i1.6304
Hermawan, D., Muhani, N., & Arisandi, S. (2022). Blood Vitamin D Levels in Hypercholesterolemic Patients. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 7(1), 101–106. https://doi.org/10.30604/jika.v7i1.818
Hermawan, D., & Widodo, S. (2021). Kadar 25(OH)D3 darah pada penderita obesitas. Jurnal Gizi Klinik Indonesia, 18(1), 1. https://doi.org/10.22146/ijcn.59751
Manousaki, D., & Richards, J. B. (2017). Low vitamin D levels as a risk factor for cancer. BMJ (Clinical Research Ed.), 359, j4952. https://doi.org/10.1136/bmj.j4952
Maruotti, N., & Cantatore, F. P. (2010). Vitamin D and the immune system. Journal of Rheumatology, 37(3), 491–495. https://doi.org/10.3899/jrheum.090797
Michael F. Holick, M. (2010). The Vitamin D Deficiency Pandemic: a Forgotten Hormone Important for Health. Public Health Reviews, 32(1), 267–283. Retrieved from https://publichealthreviews.biomedcentral.com/track/pdf/10.1007/BF03391602
Panfili, F. M., Roversi, M., D’Argenio, P., Rossi, P., Cappa, M., & Fintini, D. (2021). Possible role of vitamin D in Covid-19 infection in pediatric population. Journal of Endocrinological Investigation, 44(1), 27–35. https://doi.org/10.1007/s40618-020-01327-0
Prietl, B., Treiber, G., Pieber, T. R., & Amrein, K. (2013). Vitamin D and immune function. Nutrients, 5(7), 2502–2521. https://doi.org/10.3390/nu5072502
Sigmund, C. D. (2002). Regulation of renin expression and blood pressure by vitamin D3. Journal of Clinical Investigation, 110(2), 155–156. https://doi.org/10.1172/JCI0216160
Statsenko, Y., Al Zahmi, F., Habuza, T., Almansoori, T. M., Smetanina, D., Simiyu, G. L., … Al Koteesh, J. (2022). Impact of Age and Sex on COVID-19 Severity Assessed From Radiologic and Clinical Findings. Frontiers in Cellular and Infection Microbiology, 11(February). https://doi.org/10.3389/fcimb.2021.777070
Sulistyowati, R., Yani, F. R. W. P. F., Christyanni, Y., Agus, A., & Nusantoro, D. C. (2021). Education on the Management of Health Protocols To Avoid the Transmission of Covid-19. Jurnal Pengabdian Masyarakat Dalam Kesehatan, 3(2), 45. https://doi.org/10.20473/jpmk.v3i2.26706
Vanlint, S. (2013). Vitamin D and obesity. Nutrients, 5(3), 949–956. https://doi.org/10.3390/nu5030949
Yogani, I., Karyadi, T. H., Uyainah, A., & Koesnoe, S. (2017). Faktor-faktor yang Berhubungan dengan Kenaikan CD4 pada Pasien HIV yang Mendapat Highly Active Antiretroviral Therapy dalam 6 bulan Pertama. Jurnal Penyakit Dalam Indonesia, 2(4), 217. https://doi.org/10.7454/jpdi.v2i4.89Article Statistic
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