Brain-derived neurotrophic factor levels and anemia in elementary school children



Ena Juhaina(1Mail), Rostika Flora(2), Rico Januar Sitorus(3), Mohammad Zulkarnain(4), Ahmad Fickry Faisya(5), Nur Alam Fajar(6), N Nurlaili(7),
(1) Universitas Sriwijaya, Indonesia
(2) Universitas Sriwijaya, Indonesia
(3) Universitas Sriwijaya, Indonesia
(4) Departemen Kesehatan Masyarakat, Fakultas Kedokteran Universitas Sriwijaya, Indonesia
(5) Prodi Kesehatan Lingkungan Fakultas Kesehatan Masyarakat Universitas Sriwijaya, Indonesia
(6) Fakultas Kesehatan Masyarakat Universitas Sriwijaya, Indonesia
(7) Prodi Keperawatan Fakultas MIPA Universitas Bengkulu, Indonesia

Mail Corresponding Author


DOI : https://doi.org/10.30604/jika.v5i1.234

Full Text:    Language : En
Submitted : 2019-10-02
Published : 2019-12-13

Abstract


Iron deficiency can cause BDNF deficits in some areas of the brain. BDNF has an essential role in brain function especially memory and learning and is reported to be low in Iron Deficiency Anemia (ADB) in animal studies. ADB is vulnerable in the age group of children. The purpose of this study was to analyze the relationship between levels of Brain-Derived Neurotrophic Factor (BDNF) with the incidence of anemia in elementary school children in Seluma District. This research is an analytical observational study with a cross-sectional study design conducted in April 2019 of 50 respondents of elementary school children aged 9-12 years in Seluma Regency. Venous blood sampling was performed to measure serum BDNF levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Hb levels are measured using the Easy Touch tool. Statistical analysis using the Chi-square test. Based on the measurement results of serum BDNF levels obtained 46% of children have BDNF levels below the average (less than 3258,6084 ng/mL). Based on the results of Hb measurements, there is 30 percent of children with anemia. Bivariate analysis showed no significant relationship between BDNF levels with anemia, the Prevalence Odds Ratio (POR) was 2,250. The staff of community health center can collaborate with schools to provide counseling about anemia and its effects on school children.


Kadar brain-derived neurotrophic factor dan  anemia  pada anak sekolah dasar

Abstrak

Defisiensi zat besi dapat menyebabkan defisit BDNF di daerah tertentu dari otak. BDNF memiliki peran penting dalam fungsi otak khususnya memori dan pembelajaran dan dilaporkan rendah pada Anemia Defisiensi Zat Besi (ADB) dalam penelitian pada hewan. ADB rentan terjadi pada kelompok umur  anak-anak. Tujuan penelitian ini adalah untuk menganalisis hubungan antara kadar Brain Derived Neurotrophic Factor (BDNF) dengan kejadian anemia pada anak Sekolah Dasar di Kabupaten Seluma. Penelitian ini merupakan penelitian obsevasional analitik dengan rancangan studi cross-sectional dilaksanakan pada bulan April 2019 terhadap 50 responden anak Sekolah Dasar yang berusia 9-12 tahun di Kabupaten Seluma.  Dilakukan pengambilan darah vena untuk mengukur kadar BDNF serum dengan menggunakan metode Enzyme-Linked Immunosorbent Assay (ELISA). Kadar Hb diukur dengan menggunakan alat Easy Touch. Analisis statistik menggunakan uji Chi square. Berdasarkan hasil pengukuran kadar BDNF serum diperoleh 46% anak mempunyai kadar BDNF di bawah rata-rata (kurang dari 3258,6084 ng/mL). Berdasarkan hasil pengukuran Hb terdapat 30% anak anemia. Analisis bivariat menunjukkan tidak ada hubungan yang bermakna antara kadar BDNF dengan anemia, Prevalence Odds Ratio (POR) adalah 2,250. Petugas  Puskesmas dapat melakukan kolaborasi dengan pihak sekolah untuk memberikan penyuluhan tentang anemia dan dampaknya bagi anak sekolah.


Keywords


Anemia; Brain Derived Neurotrophic; elementary school children

References


Autry, A. E., & Monteggia, L. M. (2012). Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacological Reviews, 64(2), 238–258. https://doi.org/10.1124/pr.111.005108

Balarajan, Y., Ramakrishnan, U., Özaltin, E., Shankar, A. H., & Subramanian, S. V. (2011). Anaemia in low-income and middle-income countries. The Lancet, 378(9809), 2123–2135. https://doi.org/10.1016/S0140-6736(10)62304-5

Binder, D. K ., & Scharfman, H. E. (2008). Brain-Derived Neurotrophic Factor. Growth Factors, 22(3), 123–131. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/

Dinas Kesehatan Provinsi Bengkulu. (2018). Profil Kesehatan Bengkulu Tahun 2017. Bengkulu: Dinas Kesehatan Provinsi Bengkulu. Retrieved from https://dinkes.bengkuluprov.go.id/buku-profil-kesehatan/

Estrada, J.A., Contreas, I., Pliego-Rivero, F.B., Otero, G.A. (2014). Molecular mechanisms of cognitive impairment in iron deficiency : Alterations in brain-derived neurotrophic factor and insulin-like growth factor expression and function in the central nervous system. Nutr Neurosci, 17(5), 195–206. https://doi.org/10.1179/1476830513y.0000000084

Kemenkes. (2013). Riset Kesehatan Dasar (National Health Survey) Tahun 2013. Ministry of Health Republic of Indonesia, (1), 1–303. https://doi.org/10.1007/s13398-014-0173-7.2

Kemenkes RI. (2016). Pedoman Pencegahan dan Penanggulangan Anemia pada Remaja Putri dan wanita Usia Subur (WUS). (Adil, M., Hartini, T., Yosnelli, Firna, E., et al, Ed.). Jakarta: Direktorat Gizi Masyarakat Direktorat Jenderal Kesehatan Masyarakat Kemenkes RI. Retrieved from https://www.academia.edu/37154483/Buku_Pedoman_Pencegahan_dan_Penanggulangan_Anemia_Pada_Remaja_Putri_dan_WUS

Khomsan. (2012). Ekologi Masalah Gizi, Pangan dan Kemiskinan. Bandung: Alfabeta. Retrieved from https://www.researchgate.net/publication/304467989_Kejadian_Anemia_pada_Siswa_Sekolah_Dasar

Manning, L., Laman, M., Rosanas-Urgell, A., Michon, P., Aipit, S., Bona, C., … Davis, T. M. E. (2012). Severe Anemia in Papua New Guinean Children from a Malaria-Endemic Area: A Case-Control Etiologic Study. PLoS Neglected Tropical Diseases, 6(12). https://doi.org/10.1371/journal.pntd.0001972

McDermid, J. M., & Prentice, A. M. (2006). Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host–pathogen interactions in tuberculosis and HIV. Clinical Science, 110(5), 503–524. https://doi.org/10.1042/CS20050273

Miller, J. L. (2013). Iron deficiency anemia: A common and curable disease. Cold Spring Harbor Perspectives in Medicine, 3(7), 1–13. https://doi.org/10.1101/cshperspect.a011866

Ming, G. li, & Song, H. (2011). Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions. Neuron, 70(4), 687–702. https://doi.org/10.1016/j.neuron.2011.05.001

Munoz, Pablo; Humeras, A. (2012). Iron Deficiency on Neuronal Function. Biometals, 25(4), 825–835. https://doi.org/10.1007/s10534-012-9550-x

Nassar, M. F., Younis, N. T., Nassar, J. F., El.-Arab, S. E., Mohammad. B. M. (2014). Brain derived neurotrophic growth factor and cognitive function in children with iron deficiency anemia. British Journal of Medicine and Medical Research; 2014, 4(18), 3561–3570.

Oladeinde BH, Omoregie R, Olley M, Anunibe JA, Onifade AA, & Oladeinde OB. (2012). Malaria and Anemia among Children in a Low Resource Setting In Nigeria. Iranian Journal of Parasitology, 7(3), 31–37. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3469169&tool=pmcentrez&rendertype=abstract

Permaesih, Dewi ; Herman, S. (2005). Faktor-faktor yang Mempengaruhi Anemia pada Remaja. Buletin Penelitian Kesehatan, 33(4), 162–171. Retrieved from http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/219

Perpres. (2015). Peraturan Presiden (Perpres) No. 131 Tahun 2015 tentang Penetapan Daerah Tertinggal Tahun 2015-2019. Retrieved from https://peraturan.bpk.go.id/Home/Details/41885/perpres-no-131-tahun-2015

Prihatin, A., & Irawati, A. (2011). Hubungan antara Anemia Gizi Besi terhadap Prestasi Belajar Anak Sekolah di Daerah Endemik GAKI. MGMI, 1(1), 1–8. Retrieved from http://ejournal.litbang.depkes.go.id/index.php/mgmi/article/view/7775

Madan, N., Sikka, M., Rusia, U., Sharma, S. (2011). Developmental and neurophysiologic deficits in iron deficiency in children.: “Start Your Research.” The Indian Journal of Pediatrics. https://doi.org/10.1007/512098-010-0192-0

Stevens, G. A., Finucane, M. M., De-Regil, L. M., Paciorek, C. J., Flaxman, S. R., Branca, F., … Ezzati, M. (2013). Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: A systematic analysis of population-representative data. The Lancet Global Health, 1(1), 16–25. https://doi.org/10.1016/S2214-109X(13)70001-9

WHO. (2001). Iron deficiency anaemia: assessment, prevention and control. A guide for programme managers. Geneva: World Health Organization; 2001. United Nations Children’s Fund. Retrieved from https://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf

WHO. (2011). The global prevalence of anaemia in 2011. Who. Geneva. Retrieved from https://apps.who.int?iris/hendle/10665/177094


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